Theophylline dosage adjustment during enoxacin coadministration
نویسندگان
چکیده
منابع مشابه
Effects of enoxacin on renal and metabolic clearance of theophylline in rats.
The effects of enoxacin and its metabolite 4-oxoenoxacin on the disposition of theophylline were investigated in rats. Systemic clearance of theophylline was significantly decreased by approximately 40, 46, and 50% after oral coadministration of 25, 100, and 200 mg of enoxacin per kg, respectively. No significant changes in the volume of distribution of theophylline were observed. 4-Oxoenoxacin...
متن کاملStructure-related inhibitory effect of antimicrobial enoxacin and derivatives on theophylline metabolism by rat liver microsomes.
Enoxacin, an antimicrobial fluoroquinolone with a 7-piperazinyl-1, 8-naphthyridine skeleton, is a potent inhibitor of cytochrome P-450-mediated theophylline metabolism. The present study was designed to clarify, using seven enoxacin derivatives, the molecular characteristics of the fluoroquinolone responsible for the inhibition. Three derivatives with methyl-substituted 7-piperazine rings inhib...
متن کاملMulti-unit dosage formulations of theophylline for controlled release applications.
The study was carried out to investigate the drug release profiles of multi-unit dosage formulations of theophylline consisting of both the fast and slow release components in a unit dose. The fast release component consisted of conventional granules of theophylline formed by mixing the drug powder with starch mucilage (20% w/v) while the slow release component consisted of wax granulations of ...
متن کاملRelease of Theophylline from Sustained Release Cylindrical Dosage Forms
The holt-melt extrusion technique has proven to be an advantageous method for preparation of solid dosage forms. The aim of this work was to evaluate the release profiles of sustained release cylinders produced by hot-melt extrusion. The cylinders were composed of inner and outer part, both containing theophylline [1]. Cylinders were 0.5cm or 1cm long. The two parts were extruded separately, cu...
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BACKGROUND Blood anticoagulation after heart valve replacement is a recognized difficulty all over the world. In this study, we identified the effect of amiodarone on the function of warfarin and confirmed the countermeasure by concluding the genotype distribution of vitamin K epoxide reductase complex 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) of the patient to predict the security dose of wa...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1990
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.34.5.803